Tuesday 3 February 2015

Ebola

The year 2014 was marked by a big Ebola outbreak in Africa. Unfortunately, events with negative consequences are usually the ones that get major attention of the world and are remembered for a long time. The Ebola outbreak took so many lives and instilled fear throughout the world. The reason I have chosen this story is because I want people to know more about this terrible disease and I want to pay homage to the victims.

The most severely affected countries were Sierra Leone (10561 cases, 3216 deaths), Guinea (2920 cases, 1913 deaths) and Liberia (8643 cases, 3700 deaths). (Fig. 1) The numbers shown represent suspected case and death counts reported by World Health Organization (WHO) by January 31, but they admit that the figures are underestimates, because of the difficulty in collecting the data.

                                                 Fig. 1  Map of infected countries

These countries have very weak health systems and few resources. In more developed countries it is easier to fight diseases and limit the outbreak, because there are more available resources. For this reason, it is very important that poor countries get all the help they need in order to avoid further outbreaks.

The first cases of a mysterious disease with a high death rate were reported in March in the south-eastern regions of Guinea. Of the first 86 cases, 59 people died. By the end of the month, the disease had crossed the border into Liberia. In May it was confirmed also in Sierra Leone. In June MSF International (Doctors without borders) described the disease as out of control.

Ebola virus disease (EVD) (Fig. 2), or Ebola hemorrhagic fever (EHF), is a severe illness that is often fatal. Ebola was discovered in a village near the Ebola River in Zaire (currently the Democratic Republic of the Congo) in 1976. 

                                                             Fig. 2  Ebola virus

It is unknown how the virus appears in a human at the start of an outbreak; it is probably through contact with an infected animal, such as a fruit bat or primate. This virus spreads through human to human transmission by direct contact with the blood, secretion or other bodily fluids from infected people. People can get infected also through contact with a recently contaminated item or surface. It is not clear how long the virus exists on surfaces, but some evidence suggests that it can last up to six days. The virus on surfaces can be killed by bleach and chlorine. Ebola is not spread through the air or by water. Furthermore, there is no evidence of transmission by insects.

The incubation period is 2 to 21 days, but the average is 8 to 10 days. Humans become infectious when they develop symptoms. First symptoms are fatigue, fever, muscle pain, weakness, severe headache, followed by diarrhea, vomiting, internal and external bleeding. (Fig. 3) Patients die from dehydration and multiple organ failure. It is unclear why some patients survive and others die from this disease, but patients who die usually have a poor immune response to the virus. Early symptoms could be symptoms of other diseases, so it is difficult to diagnose Ebola early on.

                                                                 Fig. 3  Symptoms

There is no cure for Ebola, but with early medical support some people’s bodies are able to develop antibodies to fight it off. These antibodies last for at least 10 years. Infected patients need to be rehydrated and isolated from other people, and local and state health departments need to be contacted immediately. Diagnostic tests available are ELISA (Antigen-capture enzyme-linked immunosorbent assay) and PCR (Polymerase chain reaction). There is no standard treatment for Ebola, only supportive therapy is available. Researchers are trying to find an effective vaccine against this virus by using several experimental methods. Unfortunately, there is no vaccine available currently.

Medical workers are the ones that are the most exposed and often get infected, because they spend a lot of time treating infected patients. This can occur especially if they are not wearing appropriate protective equipment, such as full-body suits, gloves and goggles. (Fig. 4) Instruments they are using should be disposable, or if not, they must be sterilized before being used again. Not following the protocol can cause the outbreak to amplify.

                                                             Fig. 4  Medical staff

One of the best ways to fight the virus is washing hands and improving hygiene. It is important not to touch anything in a public place that could have become contaminated.

One survivor told the BBC his story. His symptoms started with headaches, diarrhea, pains in his back and vomiting. The first doctor he saw said it was Malaria. After he was told that he had the Ebola virus. A short while after he was admitted to the hospital for treatment he started feeling better. He said: “This was a lesson on a spiritual level and it has changed the way I look at life. The short time we spent in hospital has really transformed us. I feel lucky. I feel very happy to be alive.” (BBC News Africa, http://www.bbc.com/news/world-africa-27112397)

The Ebola outbreak is an issue of global significance, because if we don’t do something concrete about it, it is going to spread all around the world. 

Here you can see some explanations about the 2014 Ebola outbreak.

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